Aktuelle Publikationen


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Aktuelle Publikationen aus Klinik und Forschung (Auswahl)

der Medizinischen Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie (CBF)


  • Scherger, A.K., Al-Maarri, M., Maurer, H.C., (...), Wunderlich, F.T., Rose-John, S., Keller, U.: Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma. JCI Insight. 2019;4.
  • Hüllein, J., Słabicki, M., Rosolowski, M., (...) Keller, U., Huber, W., Zenz, T.: MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma. Cancer Res. 2019;79:3125-38.
  • Weber, J., de la Rosa, J., Grove, C.S., (...) Keller, U., Vassiliou, G.S., Cadiñanos, J., Bradley, A., Rad, R.: PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice. Nat Commun. 2019;10:1415.
  • von Hoff, L., Kärgel, E., Franke, V., (...) Akalin, A., Mathas, S., Scheidereit, C.: Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma. Blood. 2019;133:1489-94.
  • Edginton-White, B., Cauchy, P., Assi, S.A., (...) Mathas, S., Cockerill, P.N., Bonifer, C.: Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma. Leukemia. 2019;33:1463-74.
  • Storck, K., Brandstetter, M., Keller, U., Knopf, A.: Clinical presentation and characteristics of lymphoma in the head and neck region. Head Face Med. 2019;15(1):1.
  • O'Connor, T., Zhou, X., Kosla, J., (...) von Baumgarten, L., Keller, U., Heikenwalder, M.:Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention. Cancer Cell. 2019;36(3):250-267.
  • Fuchs, M., Goergen, H., Kobe, C., (...) Keller, UB., (...) Dietlein, M., Borchmann, P., Engert, A.: Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma: Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group. J Clin Oncol. 2019:JCO1900964.


  • Schroeder, M.P., Bastian, L., Eckert, C., (...) Serve, H., Neumann, M., Baldus, C.D.: Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures. Sci Rep. 2019;9:4188.
  • Bastian, L., Schroeder, M.P., Eckert, C., (...) Gökbuget, N., Neumann, M., Baldus, C.D.: PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia. Leukemia. 2019.
  • James, A.R., Schroeder, M.P., Neumann, M., (...) Serve, H., Akalin, A., Baldus, C.D.: Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia. J Hematol Oncol. 2019;12:8.

Weitere hämato-onkologische Forschung

  • Maurer, S., Herhaus, P., Lippenmeyer, R., (...) Grigoleit, G.U., Keller, U., Lapa, C.: Side effects of CXC-chemokine receptor 4 - directed Endoradiotherapy with Pentixather prior to Hematopoietic Stem Cell Transplantation. J Nucl Med. 2019.
  • Nimmagadda, S.C., Frey, S., Müller, P., (...) Keller, U., Edelmann, B., Fischer, T.: SDF1α-induced chemotaxis of JAK2-V617F-positive cells is dependent on Bruton tyrosine kinase and its downstream targets PI3K/AKT, PLCγ1 and RhoA. Haematologica. 2019;104:e288-92.
  • Curran, D., Matthews, S., Rowley, S.D., (...) Schwartz, S., (...) Yeh SP, Zaja F, Szer J; ZOE-HSCT Study group collaborators: Recombinant Zoster Vaccine Significantly Reduces the Impact on Quality of Life Caused by Herpes Zoster in Adult Autologous Hematopoietic Stem Cell Transplant Recipients: A Randomized Placebo-Controlled Trial (ZOE-HSCT). Biol Blood Marrow Transplant. 2019: S1083-8791(19)30508-7
  • Bastidas, A., de la Serna, J., El Idrissi, M., (...) Schwartz, S., (...) Stadtmauer, E.A., Sullivan, K.M.; ZOE-HSCT Study Group Collaborators: Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation: A Randomized Clinical Trial. JAMA. 2019;322(2):123-133.
  • Wagner, K., Kunz, K., Piller, T., (...) Schick, M., Keller, U., Müller, S.: The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics. Cell Rep. 2019;29(2):480-494

Solide Tumore

  • Jesinghaus, M., Steiger, K., Stögbauer, F. (...) Wirth, M. (...), Klinghammer, K. (...) Combs, S.E., Weichert, W., Boxberg, M.: Pre-operative cellular dissociation grading in biopsies is highly predictive of post-operative tumour stage and patient outcome in head and neck squamous cell carcinoma. Br J Cancer. 2020
  • Lux, M.P., Böhme, S., Hücherig, S., Jeratsch, U., Kürschner, N., Lüftner, D.: Surrogate threshold effect based on a meta-analysis for the predictive value of progression-free survival for overall survival in hormone receptor-positive, HER2-negative metastatic breast cancer. Breast Cancer Res Treat. 2019;176:495-506.
  • Busse, A., Lüftner, D.: What Does the Pipeline Promise about Upcoming Biosimilar Antibodies in Oncology? Breast Care (Basel). 2019;14:10-6.
  • Lüftner, D.: Approval by Authorities Does Not Allow For Suboptimal Study Conduct but Offers New Academic Possibilities. Breast Care (Basel). 2019;14:2-3.


  • Preisler, M., Rohrmoser, A., Goerling, U., (...) Riemer, M., Heuse, S., Letsch, A.: Early palliative care for those who care: A qualitative exploration of cancer caregivers' information needs during hospital stays. Eur J Cancer Care (Engl). 2019;28:e12990.

Bioinformatik & Sonstige Forschung

  • Nagel, S.N., Steffen, I.G., Schwartz, S., Hamm, B., Elgeti, T.: Age-dependent diagnostic accuracy of clinical scoring systems and D-dimer levels in the diagnosis of pulmonary embolism with computed tomography pulmonary angiography (CTPA). Eur Radiol. 2019:4563-4571.
  • Ševa, J., (...) Lamping, M., Rieke, D., (...) Starlinger, J., Keilholz, U., Leser, U.: VIST - a Variant-Information Search Tool for precision oncology. BMC Bioinformatics. 2019;20(1):429.
  • Schumann, F., Blanc, E., Messerschmidt, C., Blankenstein, T., Busse, A., Beule, D.: SigsPack, a package for cancer mutational signatures. BMC Bioinformatics. 2019;20(1):450.