Aktuelle Publikationen

 

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Aktuelle Publikationen aus Klinik und Forschung (Auswahl)

der Medizinischen Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie (CBF)

2020

Kroschinsky F, Middeke JM, Janz M (...) Burkard U, Berk A, Schmitz N.: Phase I dose escalation study of BI 836826 (CD37 antibody) in patients with relapsed or refractory B-cell non-Hodgkin lymphoma. Invest New Drugs. 2020

Teck AT, Urban S, Quass P, (...) Letsch A, Busse A, Walz JS, Keilholz U, Ochsenreither S.: Cancer testis antigen Cyclin A1 harbors several HLA-A*02:01-restricted T cell epitopes, which are presented and recognized in vivo. Cancer Immunol Immunother. 2020

Biederstädt, A., Hassan, Z., Schneeweis, C., Schick, M., (...) Wirth, M., (...) Reichert, M., Schneider, G., Keller, U.: SUMO pathway inhibition targets an aggressive pancreatic cancer subtype. Gut. 2020

Jesinghaus, M., Steiger, K., Stögbauer, F. (...) Wirth, M. (...), Klinghammer, K. (...) Combs, S.E., Weichert, W., Boxberg, M.: Pre-operative cellular dissociation grading in biopsies is highly predictive of post-operative tumour stage and patient outcome in head and neck squamous cell carcinoma. Br J Cancer. 2020

Poeschel V, Held, G, Ziepert M, (...) Keller U, (...) Loeffler M, Pfreundschuh M; FLYER Trial Investigators; German Lymphoma Alliance.:  Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial.  Lancet. 2020

Rambaldi A, Iurlo A, Vannucchi AM, (...) Pezzutto A, (...), Bettica P, Manzoni S, Di Tollo S.: Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study. Leukemia. 2020

Lamping M, Benary M, Leyvraz S, (...) Klinghammer K, Ochsenreither S, (...) Yaspo ML, Keilholz U, Rieke DT.: Support of a molecular tumour board by an evidence-based decision management system for precision oncology.  Eur J Cancer. 2020

Mylonas E, Yoshida K, Frick M, (...) Obenaus M, (...) Rose-Zerilli MJJ, Ogawa S, Damm F.:  Single-cell analysis based dissection of clonality in myelofibrosis.  Nat Commun. 2020

Ruhnke M, Cornely OA, Schmidt-Hieber M, (...), von Lilienfeld-Toal M, Weissinger F, Schwartz S.: Treatment of invasive fungal diseases in cancer patients - Revised 2019 Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Mycoses. 2020

Topp MS, Duell J, Zugmaier G, (...) Krönke J, (...) Minella AC, Munzert G, Einsele H.: Anti-B-Cell Maturation Antigen BiTE Molecule AMG 420 Induces Responses in Multiple Myeloma.  J Clin Oncol. 2020

 

2019

Scherger, A.K., Al-Maarri, M., Maurer, H.C., (...), Wunderlich, F.T., Rose-John, S., Keller, U.: Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma. JCI Insight. 2019;4.

Hüllein, J., Słabicki, M., Rosolowski, M., (...) Keller, U., Huber, W., Zenz, T.: MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma. Cancer Res. 2019;79:3125-38.

Weber, J., de la Rosa, J., Grove, C.S., (...) Keller, U., Vassiliou, G.S., Cadiñanos, J., Bradley, A., Rad, R.: PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice. Nat Commun. 2019;10:1415.

von Hoff, L., Kärgel, E., Franke, V., (...) Akalin, A., Mathas, S., Scheidereit, C.: Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma. Blood. 2019;133:1489-94.

Edginton-White, B., Cauchy, P., Assi, S.A., (...) Mathas, S., Cockerill, P.N., Bonifer, C.: Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma. Leukemia. 2019;33:1463-74.

Storck, K., Brandstetter, M., Keller, U., Knopf, A.: Clinical presentation and characteristics of lymphoma in the head and neck region. Head Face Med. 2019;15(1):1.

O'Connor, T., Zhou, X., Kosla, J., (...) von Baumgarten, L., Keller, U., Heikenwalder, M.:Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention. Cancer Cell. 2019;36(3):250-267.

Fuchs, M., Goergen, H., Kobe, C., (...) Keller, UB., (...) Dietlein, M., Borchmann, P., Engert, A.: Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma: Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group. J Clin Oncol. 2019:JCO1900964.

Schroeder, M.P., Bastian, L., Eckert, C., (...) Serve, H., Neumann, M., Baldus, C.D.: Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures. Sci Rep. 2019;9:4188.

Bastian, L., Schroeder, M.P., Eckert, C., (...) Gökbuget, N., Neumann, M., Baldus, C.D.: PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia. Leukemia. 2019.

James, A.R., Schroeder, M.P., Neumann, M., (...) Serve, H., Akalin, A., Baldus, C.D.: Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia. J Hematol Oncol. 2019;12:8.

Maurer, S., Herhaus, P., Lippenmeyer, R., (...) Grigoleit, G.U., Keller, U., Lapa, C.: Side effects of CXC-chemokine receptor 4 - directed Endoradiotherapy with Pentixather prior to Hematopoietic Stem Cell Transplantation. J Nucl Med. 2019.

Nimmagadda, S.C., Frey, S., Müller, P., (...) Keller, U., Edelmann, B., Fischer, T.: SDF1α-induced chemotaxis of JAK2-V617F-positive cells is dependent on Bruton tyrosine kinase and its downstream targets PI3K/AKT, PLCγ1 and RhoA. Haematologica. 2019;104:e288-92.

Curran, D., Matthews, S., Rowley, S.D., (...) Schwartz, S., (...) Yeh SP, Zaja F, Szer J; ZOE-HSCT Study group collaborators: Recombinant Zoster Vaccine Significantly Reduces the Impact on Quality of Life Caused by Herpes Zoster in Adult Autologous Hematopoietic Stem Cell Transplant Recipients: A Randomized Placebo-Controlled Trial (ZOE-HSCT). Biol Blood Marrow Transplant. 2019: S1083-8791(19)30508-7

Bastidas, A., de la Serna, J., El Idrissi, M., (...) Schwartz, S., (...) Stadtmauer, E.A., Sullivan, K.M.; ZOE-HSCT Study Group Collaborators: Effect of Recombinant Zoster Vaccine on Incidence of Herpes Zoster After Autologous Stem Cell Transplantation: A Randomized Clinical Trial. JAMA. 2019;322(2):123-133.

Wagner, K., Kunz, K., Piller, T., (...) Schick, M., Keller, U., Müller, S.: The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics. Cell Rep. 2019;29(2):480-494

Lux, M.P., Böhme, S., Hücherig, S., Jeratsch, U., Kürschner, N., Lüftner, D.: Surrogate threshold effect based on a meta-analysis for the predictive value of progression-free survival for overall survival in hormone receptor-positive, HER2-negative metastatic breast cancer. Breast Cancer Res Treat. 2019;176:495-506.

Busse, A., Lüftner, D.: What Does the Pipeline Promise about Upcoming Biosimilar Antibodies in Oncology? Breast Care (Basel). 2019;14:10-6.
Lüftner, D.: Approval by Authorities Does Not Allow For Suboptimal Study Conduct but Offers New Academic Possibilities. Breast Care (Basel). 2019;14:2-3.

Preisler, M., Rohrmoser, A., Goerling, U., (...) Riemer, M., Heuse, S., Letsch, A.: Early palliative care for those who care: A qualitative exploration of cancer caregivers' information needs during hospital stays. Eur J Cancer Care (Engl). 2019;28:e12990.

Nagel, S.N., Steffen, I.G., Schwartz, S., Hamm, B., Elgeti, T.: Age-dependent diagnostic accuracy of clinical scoring systems and D-dimer levels in the diagnosis of pulmonary embolism with computed tomography pulmonary angiography (CTPA). Eur Radiol. 2019:4563-4571.

Ševa, J., (...) Lamping, M., Rieke, D., (...) Starlinger, J., Keilholz, U., Leser, U.: VIST - a Variant-Information Search Tool for precision oncology. BMC Bioinformatics. 2019;20(1):429.

Schumann, F., Blanc, E., Messerschmidt, C., Blankenstein, T., Busse, A., Beule, D.: SigsPack, a package for cancer mutational signatures. BMC Bioinformatics. 2019;20(1):450.

Çakmak-Görür N, Radke J, Rhein S, (...) Heppner FL, Blankenstein T, Pezzutto A.: Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies. Leukemia. 2019

Horwitz S, O'Connor OA, Pro B, (...) Manley T, Trümper L; ECHELON-2 Study Group.: Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial. Lancet. 2019

Nagel SN, Kim D, Wylutzki T, (...) Schwartz S, Penzkofer T, Hamm B, Elgeti T.:  Diagnostic Performance and Reliability of Non-Enhanced Imaging Characterization Quotients for the Differentiation of Infectious and Malignant Pulmonary Nodules in Hematological Patients Using 3T MRI.  Rofo. 2019

Kotrova M, Volland A, Kehden B, (...) Schwartz S, Baldus CD, Gökbuget N, Brüggemann M.:  Comparison of minimal residual disease levels in bone marrow and peripheral blood in adult acute lymphoblastic leukemia. Leukemia. 2019

Klinghammer K, Gauler T, Dietz A, (...) Martus P, Knoedler M, Keilholz U:  Cetuximab, fluorouracil and cisplatin with or without docetaxel for patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (CeFCiD): an open-label phase II randomised trial (AIO/IAG-KHT trial 1108).  Eur J Cancer. 2019

Barnell EK, Waalkes A, Mosior MC, (...) Rieke D, (...) Griffith M, Salipante SJ, Griffith OL:  Open-Sourced CIViC Annotation Pipeline to Identify and Annotate Clinically Relevant Variants Using Single-Molecule Molecular Inversion Probes.  JCO Clin Cancer Inform. 2019

Schwartz S, Cornely OA, Hamed K, (...) Rahav G, Herbrecht R, Heinz WJ.: Isavuconazole for the treatment of patients with invasive fungal diseases involving the central nervous system.  Med Mycol. 2019

Garralda E, Fiedler W, Matos I, (...) Klinghammer K, (...) Baumeister H, Ochsenreither S, Zurlo A.: Preliminary results in colorectal cancer (CRC) patients enrolled in the GATTO study, a phase I study of Tomuzotuximab in combination with Gatipotuzumab in patients with EGFR positive solid tumors.  Ann Oncol. 2019