Projects of the Keller Group
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Currently, the Keller Group focuses on the following research projects:
Myc-associated cancer biology
Functional genomic screening
Aberrant Ub/SUMO activity in cancer
Chemokine receptor signaling
SUMOi drives induction of the MHC-I/APM pathway in tumor cells and the activation of T cells. When both cell types are combined, SUMOi drives a feed-forward mechanism amplifying the antitumor immune response.