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Prof. Dr. med. Jan Krönke

Professor für Pathogenese hämatopoetischer Neoplasien

Charité - Universitätsmedizin Berlin
Hindenburgdamm 30
12203 Berlin

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Weitere Informationen

Selected Publications:

Bohl S, Schmalbrock L, Bauhuf I,..., Krönke J. Comprehensive CRISPR-Cas9 screens identify genetic determinants of drugresponsiveness in multiple myeloma. Blood Advances. 2021 May 11;5(9):2391-2402

Röhner, L., Ng, Y.L.D.,… Krönke, J. Generation of a lenalidomide-sensitive syngeneic murine in vivo multiple myeloma model by expression of CrbnI391V. Exp Hematol. 2021; 93:61-69.e4.

Steinebach C, Ng D,…, Krönke J. Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders. Chemical Science. 2020; 11(13): 3474-3486

Meyer T, Jahn N, Lindner S,…, Krönke J. Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1). Leukemia. 2020 Feb;34(2):404-415.

Steinebach C, Lindner S, Udeshi ND,…, Krönke J†. Homo-PROTACs for the Chemical Knockdown of Cereblon. ACS Chem Biol. 2018;13(9):2771-82.

Krönke J*, Fink E*, Hollenbach P,…, Ebert B. Lenalidomide induces ubiquitination and degradation of casein kinase 1A1 in del(5q) MDS. Nature. 2015;523(7559):183-8. *Equal contribution.

Krönke J, Udeshi ND, Narla A, …, Ebert BL. Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science. 2014;343(6168):301-5.

Krönke J, Bullinger L, Teleanu V, ..., Döhner K. Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia. Blood. 2013;122(1):100-8.

Krönke J, Schlenk RF, Jensen KO,…, Döhner K. Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian acute myeloid leukemia study group. J Clin Oncol. 2011;29(19):2709-16





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